FOR RESEARCHERS
Question the evidence.
Connect the disciplines.
A dedicated space for critical appraisal, methodological context and interdisciplinary research questions across oral, systemic and population health.
CONTRIBUTION LIBRARY
All contributions
CLINICAL PERSPECTIVE · INTEGRATED ORAL ASSESSMENT
Periodontitis and OPMDs: Shared Risks and Clinical Relevance
Two conditions, one patient: a proportionate approach to integrated examination, modifiable risks, established care, timely referral and surveillance.
Read PerioMed Original 06 →PAPER AUTHOR · Giorgia Pieretto and colleagues
Periodontitis as a Modulator of Malignant Transformation in Oral Potentially Malignant Disorders
A critical translation separating biological plausibility from independent prognostic evidence and demonstrated clinical benefit in the relationship between periodontitis and OPMD progression.
Read the translation →
ECOLOGY · MECHANISM · HUMAN DATA · LIMITS
The Oral Microbiome Beyond the Mouth
Martina Sansavini and Julia M. Sobczyńska connect four papers and ask how far current oral–systemic microbiome evidence allows us to go.
Watch Literature Lens 01 →ORAL MICROBIOME · NEUROINFLAMMATION · CAUSALITY
The oral microbiome–brain axis
Current evidence and proposed mechanisms linking oral microbial ecosystems with neurological health—while keeping biological plausibility distinct from causality.
Read PerioMed Original 05 →PAPER AUTHOR · Weiqi Hu and colleagues
Oral microbiome, periodontal disease and systemic bone-related diseases in the era of homeostatic medicine
A critical translation of the proposed links between oral microbial dysbiosis, inflammation and systemic bone-related diseases, with clear limits around causality and clinical application.
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METHODS · INTERPRETATION · CAUSALITY
Myth vs Evidence: Association versus Causation
Martina Sansavini and Mukund Gupta examine four familiar oral–systemic claims and ask what the evidence actually supports.
Watch Myth vs Evidence 01 →CLINICAL RESEARCH · EPIDEMIOLOGY
Association and Causality in Clinical and Epidemiological Research
How study design, bias, confounding and triangulation move evidence from an observed relationship towards a defensible causal interpretation.
Read PerioMed Original 04 →PAPER AUTHOR · Max G. P. Schoenmakers and colleagues
The Association of Periodontitis With Cardiovascular Disease Parameters: A Synthesis of Systematic Reviews
A methodological translation using the periodontal–cardiovascular literature to explain why association does not, by itself, establish causation.
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PERIODONTAL MEDICINE · SYSTEMIC DISEASE
Periodontal Medicine Rewired
Mario Romandini and Giacomo Baima discuss the mechanisms linking periodontitis to systemic diseases.
Watch Expert Dialogue 02 →MULTIDISCIPLINARY PERSPECTIVE
The interplay between oral and systemic inflammation
From biological links to clinical relevance, with careful attention to causality, clinical meaning and the strength of evidence.
Read PerioMed Original 03 →PAPER AUTHOR · George Hajishengallis and Triantafyllos Chavakis
Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities
How microbial dissemination, systemic inflammation and bone-marrow adaptation may connect periodontitis with inflammatory comorbidities.
Read the translation →
PERIODONTOLOGY · CARDIOVASCULAR HEALTH
The Oral–Cardiovascular Link
Professor Francesco D’Aiuto discusses what the evidence can—and cannot yet—tell us about periodontal and cardiovascular health.
Watch Expert Dialogue 01 →EDITORIAL PERSPECTIVE
Can periodontal inflammation leave an immune memory?
Trained immunity as a possible biological link between periodontal inflammation and cardiovascular biology.
Read PerioMed Original 02 →PAPER AUTHOR · Mariano Sanz and colleagues
Periodontitis and cardiovascular diseases: Consensus report
A joint periodontal and cardiovascular consensus connecting epidemiology, biological pathways, treatment response and coordinated clinical care.
Read the translation →
ORAL HEALTH · MEDICINE · PUBLIC HEALTH
When the Mouth Joins the Health Conversation
Three voices explore why oral and systemic health need a shared conversation across dentistry, medicine and public health.
Watch PerioMed Voices 01 →INTERDISCIPLINARY PERSPECTIVE
Beyond the Silos
Why we built PerioMed Global: three perspectives connecting oral health, the whole patient and population health without losing scientific identity.
Read PerioMed Original 01 →PAPER AUTHOR · Purnima S. Kumar
From focal sepsis to periodontal medicine
A critical translation of a century of research on the oral microbiome, systemic disease and the limits between association and causation.
Read the translation →RESEARCHER WORKSPACE
Look beyond the headline.
Evidence Translation
Scientific literature identified, critically appraised and translated without losing its methodological context.
Methods & uncertainty
Closer attention to study design, interpretation, limitations and the questions that remain unanswered.
Research connections
Opportunities to see how periodontal, medical, biological and population-health perspectives inform one another.